MGR – Abortive Migraine Supplement

Other products can take up to 2 hours to show signs of pain relief. With MGR, most patients report relief within minutes! 

How? Taking encapsulated ginger, or other products internally means it has to travel through the stomach and entire intestinal tract before being absorbed into the bloodstream. With MGR, the formula is absorbed through mucous membranes under your tongue for direct uptake into the bloodstream. The sublingual portal is one of the fastest ways to get things into your bloodstream, next to getting an IV. 

As a bonus, if you have nausea and want to relieve symptoms, you can swallow MGR instead for both pain AND nausea relief!

We’ve optimized a proprietary extraction method for our sublingual oils to isolate the active, fat-soluble compounds in ginger and provide you with a standardized extract determined by third-party testing. This means you know exactly what you’re getting when you use this product.

This is a standardized extract using a proprietary extraction process. We do third-party testing with a company called Eurofins Product Testing US. We test for gingerols and shogaols, and will standardize the extract to those compounds.

What does the research say?

Ginger (Zingiber Officinale Roscoe) is a climbing perennial plant, indigenous to southeastern Asia⁶. It was been used in many forms of traditional medicine for centuries and more recently has been explored for its various chemical substances with pharmacological properties.

Ginger has been shown to mitigate the effects of pain through a variety of pathways, such as:

• Inhibiting prostaglandins via the COX and LOX pathways⁶
• Increasing antioxidant activity by inhibiting xanthine oxidase, which is mainly involved in the generation of reactive oxygen species (ROS)⁶
• Inhibiting the transcription factor nf-kB⁶
• Acts as an agonist of the vanillin nociceptor, a potent analgesic⁶

Studies have already begun to demonstrate the effectiveness of ginger for the abortion of migraine.

• In 2011¹ a study showed a reduction of pain in 63% of the migraine group within 2 hours using a ginger/feverfew combination.
• In 2013 a study⁵ compared patient satisfaction between sumatriptan and ginger for treating migraine. They found:
  • Efficacy of ginger powder and sumatriptan was similar. 
  • Two hours after using either drug, mean headaches severity decreased significantly.
  • Clinical adverse effects of ginger powder were less than sumatriptan. 
  • The effectiveness of ginger powder in the treatment of common migraine attacks is statistically comparable to sumatriptan.
  • Ginger also poses a better side effect profile than sumatriptan.
• In 2018 a study⁴ compared the addition of ginger to ketoprofen to assess for differences. They found:
  • Patients treated with ginger showed significantly better clinical response after 1 h.
  • Ginger treatment promoted reduction in pain and improvement on functional status at all times assessed.
  • Concluding that the addition of ginger to non-steroidal anti-inflammatory drugs may contribute to the treatment of migraine attack.
• In 2020 a meta-analysis summed up the general findings by saying:
  • Compared with control group in migraine patients, ginger treatment is associated with substantially improved pain free at 2 h²
  • The incidence of nausea and vomiting is obviously lower in ginger group than that in control group.²
  • Conclusions: Ginger is safe and effective in treating migraine patients with pain outcomes assessed at 2 h.²

There has also been interested in ginger as a preventative, however a recent study shows that ginger is not effective in the prevention of migraine. The study concluded that ‘ginger provides no greater benefit in the prophylactic treatment of migraine when compared to placebo’.³

Taking all of this into account, MGR was created to deliver a powerful form of ginger in the one of the quickest ways possible, sublingually. This is also why you’ll see that MQ-7 intentionally omits ginger from its ingredients as it has not only been shown not to be helpful, but it may also be counterproductive if using ginger as an abortive.

Bibliography

1. Cady RK, Goldstein J, Nett R, Mitchell R, Beach ME, Browning R (2011). A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 51: 1078–1086.
2. Chen L, Cai Z. The efficacy of ginger for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2020 Nov 17:S0735-6757(20)31039-1. doi: 10.1016/j.ajem.2020.11.030. Epub ahead of print. PMID: 33293189.
3. Martins LB, Rodrigues AMDS, Monteze NM, Tibaes JRB, Amaral MHA, Gomez RS, Teixeira AL, Ferreira AVM. Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine. Cephalalgia. 2019 Aug 9:333102419869319. doi: 10.1177/0333102419869319. [Epub ahead of print] PubMed PMID: 31398997.
4. Martins LB, Rodrigues AMDS, Rodrigues DF, Dos Santos LC, Teixeira AL, Ferreira AVM. Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment. Cephalalgia. 2018 Jan 1:333102418776016. doi: 10.1177/0333102418776016. [Epub ahead of print] PubMed PMID: 29768938.
5. Maghbooli M, Golipour F, Moghimi Esfandabadi A, Yousefi M. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res. 2014 Mar;28(3):412-5. doi: 10.1002/ptr.4996. Epub 2013 May 9. PubMed PMID: 23657930.
6. Rondanelli M, Fossari F, Vecchio V, Gasparri C, Peroni G, Spadaccini D, Riva A, Petrangolini G, Iannello G, Nichetti M, Infantino V, Perna S. Clinical trials on pain lowering effect of ginger: A narrative review. Phytother Res. 2020 Nov;34(11):2843-2856. doi: 10.1002/ptr.6730. Epub 2020 May 20. PMID: 32436242; PMCID: PMC7754412.