Leptin is one of the most influential hormones in the regulation of fat stores in our bodies.
It is secreted by adipocytes (fat cells) and is used as a “signaling molecule” from the to the brain. Leptin is secreted into bloodstream from the adipocytes. When it reaches the hypothalamus gland in your brain, it binds to receptors and a signal is transmitted to the rest of your body.
Low levels of leptin – between 4-6 ng/dl. But high levels dominate in the bloodstream of some individuals who are overweight. Normally, when Leptin levels rise, the brain will turn off the mechanism and suppress the appetite. But if you have elevated levels over a long period of time, the cells in the hypothalamus lose the ability to reduce appetite making you hungry all of the time.
If you feel hungry all of the time, you may have elevated leptin levels and, if you do, you will not be able to lose weight until you get them under control. In addition, since the target area for leptin is the hypothalamus, leptin can influence the other functions of the hypothalamus which include, cortisol regulation, blood sugar regulation, thermogenesis (regulation of body temperature), and thyroid function.
If you are overweight, your doctor must check fasting leptin levels. If they are above 10ng/dl you need to seek out a qualified professional who can help you lower your levels.